What Are CMS' Part B Rebatable Drugs for 2025?

We’ve got the Centers for Medicare & Medicaid Services’ (CMS) most recent list of Medicare Part B drugs your clients may pay reduced coinsurance for from July through September 2025!

CMS publishes the Medicare Part B rebatable drugs quarterly. Keep reading to see the latest Part B rebate guidance.

Inflation-Adjusted Coinsurances for Medicare Part B Drugs

As a reminder, Medicare Part B generally covers drugs provided in doctors’ offices and hospital outpatient departments. Part B drugs may qualify for price adjustments as a result of the Medicare Prescription Drug Inflation Rebate provision in the Inflation Reduction Act (IRA).

The provision states that drug manufacturers who increase the prices of their drugs faster than the rate of inflation must reimburse Medicare for the difference. The reimbursement comes in the form of a rebate, hence the name “Part B rebatable drugs.” CMS then passes the savings back to Medicare enrollees through inflation-adjusted Part B coinsurances.

In December 2024, CMS reported that Medicare beneficiaries have seen savings on more than 120 drugs thanks to the IRA’s Medicare Part B inflation rebate program.

Part B Drugs Eligible for Reduced Coinsurance in 2025

In June 2025, CMS published their July 2025 ASP Pricing File, noting the 86 Part B prescription drugs that may have lower beneficiary coinsurance rates for July, August, and September due to their prices increasing faster than inflation.

Note: CMS released information on inflation-adjusted coinsurances via their quarterly Average Sales Price (ASP) public files. Occasionally, CMS updates these after they release them, before the changes go into effect.

Q3 2025 Part B Rebatable Drugs

DrugInflation-Adjusted Coinsurance
Percentage (Normally 20%)
Inj., omadacycline, 1 mg19.910
Inj., eravacycline, 1 mg19.167
Inj velmanase alfa-tycv 1 mg18.949
Injolipudase alfa-rpcp 1mg19.894
Inj, remdesivir, 1 mg19.896
Inj, amiodarone (nexterone)11.609
Inj, rezafungin, 1 mg19.693
Inj, abilify maintena, 1 mg19.858
Peng benzathine/procaine inj16.839
Penicillin g benzathine inj12.595
Inj, brixadi, 7 days or less19.735
Injection, burosumab-twza 1m18.612
C-1 esterase, berinert18.407
Canakinumab injection19.883
Inj ceftolozane tazobactam17.660
Collagenase, clost hist inj18.060
Denosumab injection17.422
Inj, fosaprepitant (teva)7.136
Galsulfase injection19.774
Inj cuvitru, 100 mg19.621
Hizentra injection19.318
Hyqvia 100mg immuneglobulin19.596
Inj, panzyga, 500 mg18.013
Hemin, 1 mg18.799
Dalteparin sodium11.620
Inj., ibalizumab-uiyk, 10 mg19.695
Inj, spesolimab-sbzo, 1 mg19.534
Leuprolide acetate /3.75 mg18.281
Inj, meropenem (b. braun)9.587
Inj, mirikizumab-mrkz, 1 mg14.826
Naltrexone, depot form19.692
Inj ublituximab-xiiy, 1 mg19.538
Palifermin injection16.184
Inj, invega hafyera/trinza19.423
Inj, pasireotide long acting15.139
Pegloticase injection19.360
Pegunigalsidase alfa-iwxj19.653
Inj, romiplostim 1 microgram18.178
Injection, siltuximab18.284
Inj. eptinezumab-jjmr 1 mg19.095
Inj talquetamab-tgvs 0.25 mg19.315
Tenecteplase injection19.043
Inj. romosozumab-aqqg 1 mg18.829
Testosterone undecanoate 1mg19.097
Triamcinolone a inj prs-free3.852
Inj., triptorelin xr 3.75 mg19.596
Antithrombin iii injection19.670
Inj. jivi 1 iu19.204
Inj, kovaltry, 1 i.u.19.554
Inj, ixinity, 1 i.u.19.840
Tacrol envarsus ex rel oral19.465
Lymphocyte immune globulin11.445
Tacrolimus injection19.983
Oral netupitant, palonosetro18.767
Inj, aspara, rylaze, 0.1 mg19.330
Injection, belinostat, 10mg19.708
Injection, blinatumomab18.197
Brentuximab vedotin inj17.773
Injection, carfilzomib, 1 mg17.848
Inj, amivantamab-vmjw18.764
Inj daunorubicin, cytarabine19.310
Inj enfort vedo-ejfv 0.25mg19.254
Inj gemcitabine hcl (accord)18.251
Ixabepilone injection19.632
Inj. isatuximab-irfc 10 mg19.844
Pegaspargase injection18.410
Pentostatin injection18.819
Inj. tagraxofusp-erzs 10 mcg19.787
Inj tisotu vedotin-tftv, 1mg18.990
Inj nivol relatlimab 3mg/1mg19.731
Obinutuzumab inj19.941
Panitumumab injection18.100
Injection, pertuzumab, 1 mg19.453
Pralatrexate injection19.376
Inj talimogene laherparepvec18.663
Inj,ado-trastuzumab emt 1mg19.821
Inj fam-trastu deru-nxki 1mg19.663
Inj lon tesirin-lpyl 0.075mg18.977
Inj teclistamab cqyv 0.5 mg19.748
Axicabtagene ciloleucel car+18.015
Tisagenlecleucel car-pos t17.866
Brexucabtagene car pos t19.610
Lisocabtagenemara car pos t18.687
Idecabtagene vicleucel car19.119
Ciltacabtagene car-pos t19.101

Source: CMS.gov

How Much Could Beneficiaries Save on These Prescriptions?

According to 2024 CMS Administrator Chiquita Brooks-LaSure, “As we head into 2025, people with Medicare will feel substantial relief from high drug prices. In addition to lower cost-sharing for certain drugs whose prices have increased above the rate of inflation, people with Medicare prescription drug coverage will have their annual out-of-pocket costs capped at $2,000 for the first time. This will be life-changing for people who have been living with high drug costs.”

It’s important to note that specific savings will depend on the individual and their exact coverage.

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For more info on the Medicare Prescription Drug Rebate Program, visit CMS.gov/inflation-reduction-act-and-medicare/inflation-rebates-medicare.

Not affiliated with or endorsed by Medicare or any government agency.

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